Biomed analysis: keep traditional knowledge open but safe

The availability of such databases, and the willingness of developed nations to consult them during patent applications, are vital to protect the traditional knowledge of countries like China and India.

Not all developing countries have the resources to fight such wars. And doing so eats into budgets that could otherwise be spent using traditional knowledge to develop new and urgently needed treatments for diseases such as malaria.

But by providing access to traditional medicine compounds, they could also open the doors for a new wave of drug discovery.

Promise of traditional medicines

So far, attempts to bring traditional medicines into treatment practices in the developed world have largely failed. Traditional remedies are often bespoke to an individual, and the exact combination of ingredients for even common treatments may vary - which is anathema to commercial standardisation.

Nevertheless, the ability to screen libraries of traditionally used chemical compounds offers much promise that some developing countries are now quick to exploit.

The African Network for Drugs and Diagnostics Innovation, for example, includes the development of new treatments for infectious diseases from traditional medicines as one of its goals. It is pursuing this on its own and in collaboration with initiatives such as the Global Institute for Bio-Exploration, a global network that is investigating plant-based pharmaceuticals for diseases such as tuberculosis and malaria.

Meanwhile, the Indian Council of Medical Research's Advanced Centre for Reverse Pharmacology in Traditional Medicine, in Mumbai, is undertaking a similar approach to drug discovery, studying for example the anti malarial properties of a type of jasmine known locally as parijat.

WIPO weighs in

Of course, offering free information on traditional compounds still carries the risk of exploitation.

Devinder Sharma, chair of the Forum for Biotechnology and Food Security in New Delhi, told SciDev.Net that "TKDL facilitates biopiracy. With patent applications becoming sophisticated and huge, it is never possible to find out in which cases companies have used the information from TKDL."

Sharma adds that international guidelines and laws should be changed so that "any patent application found to be based on traditional knowledge would attract a penalty and the blacklisting of the company".

Brahmachari disagrees. He points to the success of the open-access consensus for sequencing the human genome as proof that the TKDL will work the way it is intended to.

But ensuring that it does may owe more to the support of the World Intellectual Property Organization (WIPO). In a press conference this month, WIPO director-general Francis Gurry called the "sophisticated" TKDL "a model we hope to establish in other countries around the world".

Patents only work because there are consequences from their infringement. As long as open-access traditional knowledge databases have the backing of the 'big guns' in intellectual property - both nationally and internationally - there is a good chance that traditional medicine can be brought into the modern world.