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Stop calling for more funding and use what you've got better

By John Zalcberg - posted Monday, 29 August 2011


Indeed the very process of planning and conducting trials of novel therapies forces clinicians to standardise current treatment strategies based on the best available evidence, thereby improving care even before the results of the trial are known. But recently, external factors such as the high Australian dollar and more attractive investment climate in Asia, has diverted funding into other markets.

As a result, we risk losing our status and expertise as growing numbers of trials move to Asia. With their large populations and increasing subsidies for clinical trials, South Korea and Taiwan are already formidable competitors in the region.

In order to ensure that medical research capabilities continue to flourish it is critical that Australia focuses on further research investment in clinical and translational research. It is this cutting edge research which will be of most benefit to health outcomes for Australians and bolster our international position in the long-term.

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An example of this is playing out around Australian cancer centres. The Australasian Gastro-Intestinal Trials Group is currently investigating a new approach which will change the way we treat pancreatic cancer.

Trials conducted to date have shown that cancers are radically different between people and respond differently to treatment. This research revolutionises the conventional approach of focussing on the affected organ. Personalised treatments focus on the development of biomarkers to help researchers and clinicians select the optimal treatment for each individual patient by investigating the molecular markers in each person's tumour.

This will hopefully minimise the number of cancer patients who undergo ineffective treatment and also provide significant cost savings on expensive and unnecessary treatments. This is where the future of cancer research and its treatment lies.

Since trials first began in 1991, in collaboration with the National Health and Medical Research Council (NHMRC) Clinical Trials Centre, the AGITG has improved cancer outcomes through a range of clinical trials.

These include using oral chemotherapy as a less invasive alternative to intravenous therapies, pre-operative chemo radiation for locally advanced oesophageal cancer, as well as improving quality of life for cancer patients by identifying when to introduce palliative chemotherapy and achieving fewer side effects by using a combination of chemotherapies. These and trials like them have helped develop and maintain a world-class standard of treatment in Australia.

It is a fact of life that budgets are finite. Let us therefore play to our strengths as a small yet dynamic nation by ensuring we foster innovative clinical research in order to continue to provide the best possible health care to all Australians.

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About the Author

Professor John Zalcberg is Chair of the Australasian Gastro-Intestinal Trials Group - www.gicancer.org.au.

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